PHARMACEUTICAL TECHNOLOGY III

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Learning Outcomes

Will be able to explain the basic concepts and definitions of parenteral preparations.
Reiterates basic concepts and definitions in parenteral preparation.
Define the term isotonia.
Discuss the importance of using isotonic preparations in parenteral administration.
Recognize the method of preparing isotonic solution.
Defines the term sterility.
Define the term pyrogen substance.
Will be able to explain the parenteral administration routes.
Defines intravenous (i.v.) administration.
Defines intramuscular (i.m.) administration.
It describes intradermal (i.d.) or intracutaneous (i.c.) administration.
Describe subcutaneous (s.c.) administration.
Describe intra-articular (i.a.) administration.
Describes the administration to the subarachnoid space [intrathecal (i.t.)].
Describes application to the back and lower part of the brain [intracisternal (i.s.)].
Defines intracardiac administration.
Defines intraocular administration.
Will be able to define the Injection Dosage Form.
Defines the dosage form for injection.
Lists the route of administration of the injectable dosage form.
Defines a large volume preparation for injection.
Defines a small volume preparation for injection.
Defines solution for injection.
Defines injectable suspension.
Defines injectable emulsion.
Defines injectable reconstituted powder.
Defines injectable concentrated solution.
Defines injectable protein preparation.
Defines injectable modified-release system.
Defines peritoneal dialysis solution.
Defines hemodialysis solution.
Will be able to explain the formulation of injectable dosage form.
Evaluates the characteristics that the injectable formulation must possess.
Discusses the parameters that are effective in the injectable formulation.
Performs isotonic solution calculations.
Explains the preparation method of injectable preparations.
Lists the steps for preparing injectable suspension.
Lists the steps for preparing injectable emulsion.
Lists the methods for preparing injectable reconstituted powder.
Monitors the sterilization conditions of injectable dosage form.
Will be able to explain the packaging of injectable dosage form.
Recognizes the packaging materials used in the packaging of injectable dosage forms.
Explains the parameters to be considered in the packaging of injectable dosage forms.
Will be able to explain the quality control process performed in injectable dosage forms.
Lists the quality control tests for injectable dosage forms.
Evaluates the quality control test results of injectable dosage forms.
Summarizes the stability issues observed in injectable solutions.
Explains the importance of the sterility test in injectable dosage forms.
Lists the sterility test methods for injectable dosage forms.
Explains how the sterility test is performed using different methods for injectable dosage forms.
Will be able to explain the anatomy of the eye.
Recognizes the anatomical structure of the eye.
Explains the drug absorption through the corneal route.
Explains the drug absorption through the non-corneal route.
Will be able to define ophthalmic preparation.
Lists ophthalmic preparations.
Lists the characteristics that an ophthalmic preparation must possess.
Will be able to explain the ocular route of administration.
Lists ocular routes of administration.
Defines topical application.
Defines periocular injection.
Defines intraocular injection (intracameral, intravitreal).
Will be able to explain the drug disposition in ocular administration.
Lists the factors affecting drug disposition in the pre-corneal area.
Evaluates the effect of tear production and tear circulation on drug disposition.
Will be able to explain ocular bioavailability.
Defines ocular bioavailability.
Lists the factors affecting ocular bioavailability.
Defines approaches to enhance ocular bioavailability.
Will be able to explain the sterility in ophthalmic preparations.
List the sterilization methods of ophthalmic preparations.
Discuss the criteria to be considered when choosing the sterilization method for ophthalmic preparations.
Will be able to define contamination.
Defines contamination.
Classifies the sources of contamination.
Will be able to define sterilization.
Defines sterilization.
Evaluates sterilization kinetics.
Will be able to explain the sterilization method.
Classifies sterilization methods.
Lists physical sterilization methods.
Lists chemical sterilization methods.
Will be able to explain the physical sterilization method – Sterilization by heat.
Defines sterilization with saturated steam (moist heat; pressurized steam).
Defines the Bowie-Dick Test.
Defines sterilization with dry heat.
Lists the process control methods in heat sterilization.
Will be able to explain the physical sterilization method – Sterilization by radiation.
Defines sterilization methods by radiation.
Defines sterilization with UV radiation.
Will be able to explain the physical sterilization method – Sterilization by ionizing radiation.
Defines sterilization by ionizing radiation.
Defines sterilization with gamma radiation.
Lists the type of particle radiation used in sterilization by ionizing radiation.
Defines sterilization with accelerated electrons.
Will be able to explain the physical sterilization method - sterilization by filtration.
Defines sterilization by filtration.
Recognizes the filter material used in sterilization by filtration.
Will be able to explain the chemical sterilization method – ethylene oxide sterilization
Defines chemical sterilization.
Lists chemical sterilization methods.
Defines sterilization by ethylene oxide.
Will be able to explain the aseptic method.
Defines the aseptic area.
Lists the characteristics that the aseptic area must have.
Will be able to explain sterilization validation.
Defines sterilization validation.
Questions the importance of sterilization validation.
Will be able to define general information about powdered drugs.
Defines powdered drugs.
Classifies powdered drugs.
Defines the preparation methods of powdered drugs.
Will be able to explain the control performed on powdered drugs.
Lists the control performed on powdered drugs.
Lists the particle size analysis methods of powdered drugs.
Evaluates the problems that may be encountered in the mixing of powders.
Will be able to explain the packaging of powdered drugs.
Recognizes the packaging forms of powdered drugs.
Lists the packaging methods of powdered drugs.
Names the characteristics that the packaging of powdered drugs must have.
Evaluates the problems that may be encountered in the packaging of powdered drugs.
Will be able to explain the general characteristics of micro-pellets.
Defines micro-pellets.
Explains the preparation methods of micro-pellets.
Lists the control performed on micro-particles.
Will be able to explain the basic concepts and definitions in parenteral preparations.
Defines the parenteral dosage form.
Classifies the routes of administration of the parenteral dosage form.
Will be able to define the parenteral route of administration, volume, and dose.
Defines small volume injectable solution.
Defines large volume injectable solution.
Will be able to explain the components found in parenteral dosage forms.
Classifies the components found in parenteral dosage forms.
Defines injectable water.
Lists solvents that are miscible with water.
Lists solvents that are immiscible with water.
Will be able to explain the method of preparing isotonic solution."
Provides an example of the isotonic adjustment calculation for injectable dosage forms.
Performs the isotonic calculation.
Explains how to fill the ampoule.
Explains the volume excess that should be added to the fluid solution according to the solution volume.
Explains the volume excess that should be added to the viscous solution according to the solution volume.
Will be able to define sterilization.
Defines sterilization.
Explains the sterilization methods applied in laboratory conditions.
Explains the concept of the sterilization chart.
Lists the elements that should be included in the sterilization chart.
Will be able to explain sterilization control.
Explains in-process control.
Defines the examination of the process using physical indicators.
Defines the examination of the process using chemical indicators.
Defines the examination of the process using biological indicators.
Explains post-process control.
Will be able to explain the control performed on the ampoule.
Defines the control performed on the ampoule.
Classifies the control performed on the ampoule.
Will be able to define sterile neutral olive oil."
Defines the concept of acidity degree.
Explains the steps in determining the acidity degree.
Performs acidity degree determination.
Will be able to define parenteral suspension and emulsion.
Defines injectable suspension.
Defines injectable emulsion.
Will be able to define large volume parenteral solution.
Defines large volume parenteral preparation.
Defines peritoneal dialysis solution.
Will be able to explain the administration of parenteral preparations.
Explains the preparation of Novalgin ampoule.
Prepares Novalgin ampoule and delivers it in appropriate packaging.
Explains the preparation of Procaine ampoule.
Prepares Procaine ampoule and delivers it in appropriate packaging.
Explains the preparation of Vitamin C ampoule.
Prepares Vitamin C ampoule and delivers it in appropriate packaging.
Explains the preparation of Glucose ampoule.
Prepares Glucose ampoule and delivers it in appropriate packaging.
Explains the preparation of sterile neutral olive oil.
Prepares sterile neutral olive oil and delivers it in appropriate packaging."
Explains the preparation of Vitamin D3 ampoule.
Prepares Vitamin D3 ampoule and delivers it in appropriate packaging.
Explains the preparation of peritoneal dialysis solution.
Prepares peritoneal dialysis solution and delivers it in appropriate packaging.
Explains the preparation of hemodialysis solution.
Prepares hemodialysis solution and delivers it in appropriate packaging.
Will be able to explain the basic concepts and definitions in ophthalmic preparations.
Defines the ophthalmic dosage form.
Defines ocular solution (eye drops; ocula guttae, collyria).
Will be able to define the application of ocular solution.
Explains the preparation of ocular solution containing potassium iodide.
Prepares ocular solution containing potassium iodide and delivers it in appropriate packaging.
Explains the preparation of ocular solution containing zinc sulfate.
Prepares ocular solution containing zinc sulfate and delivers it in appropriate packaging.
Explains the preparation of ocular solution containing pilocarpine nitrate.
Prepares ocular solution containing pilocarpine nitrate and delivers it in appropriate packaging.
Explains the preparation of ocular solution containing atropine sulfate.
Prepares ocular solution containing atropine sulfate and delivers it in appropriate packaging.
Explains the preparation of ocular solution containing boric acid.
Prepares ocular solution containing boric acid and delivers it in appropriate packaging.
Explains the preparation of ocular solution containing borax.
Prepares ocular solution containing borax and delivers it in appropriate packaging.
Will be able to define the basic concept of nasal drops.
Defines nasal drops.
Lists the characteristics that nasal drops must have.
Will be able to explain the application of nasal drops.
Explains the preparation of nasal drops containing ephedrine hydrochloride-methyl cellulose.
Prepares nasal drops containing ephedrine hydrochloride-methyl cellulose and delivers them in appropriate packaging.
Explains the preparation of nasal drops containing ephedrine hydrochloride.
Prepares nasal drops containing ephedrine hydrochloride and delivers them in appropriate packaging.
Will be able to define the basic concept of ear drops.
Defines ear drops.
Lists the characteristics that ear drops must have.
Will be able to explain the application of ear drops.
Explains the preparation of 'Glycerine phenique' ear drops.
Prepares 'Glycerine phenique' ear drops and delivers them in appropriate packaging.
Explains the preparation of ear drops containing benzocaine.
Prepares ear drops containing benzocaine and delivers them in appropriate packaging.
Will be able to explain the basic concept of packaging.
Defines the package.
Defines the package formulation containing narcotic substances.
Explains the packaging of the package formulation.
Will be able to explain the application of the package.
Explains the preparation of the package containing papaverine hydrochloride.
Prepares the package containing papaverine hydrochloride and delivers it in appropriate packaging
Explains the preparation of the package containing menthol.
Prepares the package containing menthol and delivers it in appropriate packaging.
Will be able to explain the basic concept of a cachet.
Defines the cachet.
Explains the filling of the cachet.
Lists the cachet numbers.
Will be able to explain the basic concept of hard capsules.
Defines the hard capsule.
Explains the size of the hard capsule and the amount of powder it holds.
Will be able to explain the application of hard capsules.
Explains the preparation of hard capsules containing menthol.
Prepares hard capsules containing menthol and delivers them in appropriate packaging.
Explains the preparation of hard capsules containing theophylline.
Prepares hard capsules containing theophylline and delivers them in appropriate packaging.
Will be able to explain the basic concept of a pilular.
Defines the pilular.
Lists the characteristics that the pilular formulation must have.
Gives an example of an anti-adherent powder.